Presynaptic plasticity lab

The PrePlast lab investigates the molecular mechanisms of presynaptic function and dysfunction.

Our research focuses on the neuronal synapse, the contact site between neuronal cells where neurotransmission occurs. We study the molecules and signalling pathways that determine synaptic function and plasticity. Based on a deep understanding of the mechanisms that control physiological synaptic function, we aim to understand synaptic dysfunction in brain diseases to provide a foundation for the development of specific treatments.

We use advanced imaging of neurotransmission in living neurons derived from rodent transgenic animals or human stem cells, advanced genetics for in vivo and in vitro disease modelling, and a variety of cellular, molecular and biochemical techniques.